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Understanding the Tabletability Differences between Indomethacin Polymorphs Using Powder Brillouin Light Scattering.

Beth A Young1, Dherya Bahl1, Lewis L Stevens2

  • 1Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa, Iowa City, Iowa, 52242, USA.

Pharmaceutical Research
|August 21, 2019
PubMed
Summary
This summary is machine-generated.

The alpha polymorph of indomethacin exhibits superior tabletability due to facilitated shear, unlike the gamma form. This study reveals key structure-performance relationships for pharmaceutical tablet development.

Keywords:
crystal engineeringmechanical propertiespolymorphssolid-statetablets

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Area of Science:

  • Solid-state chemistry
  • Materials science
  • Pharmaceutical sciences

Background:

  • Indomethacin exists in multiple polymorphic forms, impacting its material properties.
  • Understanding the relationship between crystal structure and performance is crucial for drug formulation.

Purpose of the Study:

  • To investigate the tabletability of indomethacin polymorphs (α and γ) using topological and mechanical analyses.
  • To identify the structure-performance relationship influencing the tabletability of indomethacin polymorphs.

Main Methods:

  • Powder Brillouin light scattering (p-BLS) to determine mechanical properties.
  • Powder X-ray diffraction for phase identification.
  • Energy framework analysis and compression testing to assess tabletability.

Main Results:

  • Distinct acoustic frequency distributions and elastic moduli were observed for each polymorph.
  • Alpha-indomethacin showed low-velocity shear modes, indicating facilitated shear and improved plasticity.
  • Gamma-indomethacin, despite a layered structure, exhibited a higher shear modulus.

Conclusions:

  • Experimental mechanical data align with predicted interaction topologies.
  • A comprehensive molecular understanding of polymorph-specific tabletability was achieved.