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Updated: Jan 20, 2026
09:56
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
15.5K
Risk Factors for Doxorubicin-Induced Serious Hyperglycaemia-Related Adverse Drug Reactions
Jincheng Yang1, Yu Wang2, Kang Liu2
1Department of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Yangjc@cicams.ac.cn.
Summary
Doxorubicin can cause serious hyperglycemia-related adverse drug reactions (HG-ADRs). Older males are at higher risk for severe outcomes from these reactions, highlighting the importance of age and gender in patient monitoring.
Area of Science:
- Oncology
- Pharmacovigilance
- Endocrinology
Background:
- Hyperglycemia is linked to increased cancer mortality.
- Doxorubicin, used for pancreatic cancer, is a significant inducer of hyperglycemia-related adverse drug reactions (HG-ADRs).
Purpose of the Study:
- To analyze risk factors for serious doxorubicin-induced HG-ADRs.
- To identify patient demographics associated with severe outcomes.
Main Methods:
- Analysis of 558 individual case safety reports of doxorubicin-induced HG-ADRs from VigiBase (2000-2017).
- Bivariate correlation and logistic regression used to assess factors influencing outcome seriousness.
- Age stratification into five groups.
Main Results:
- 71.1% of cases had serious outcomes, and 10.9% resulted in death.
- Age and gender were significantly correlated with outcome seriousness (P < 0.01).
- Factors like year reported, ADR duration, latency, treatment duration, and dosage did not correlate with outcome seriousness.
Conclusions:
- Age and gender are significant risk factors for serious doxorubicin-induced HG-ADRs.
- Male patients and older individuals face a higher likelihood of severe outcomes.
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