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Peripheral polyneuropathy associated with Chikungunya virus infection
Vanessa P Silva1, Dacylla S Costa1, Vania C C V L Carvalho2
1Laboratory of Biochemistry and Molecular Biology of Microorganisms and Plants, Federal University of Piauí, Campus Ministro Reis Velloso-CMRV, Parnaíba, Brazil.
Journal of Neurovirology
|August 21, 2019
Summary
Chikungunya virus (CHIKV) infection in an elderly Brazilian woman led to severe arthralgia and peripheral polyneuropathy. Treatment with corticosteroids and methotrexate suggests an immune-mediated response, highlighting the need for early neuroinfection diagnosis.
Area of Science:
- Arbovirology
- Neurology
- Immunology
Background:
- Chikungunya virus (CHIKV) is an arbovirus transmitted by mosquitoes, causing febrile illness and arthralgia.
- CHIKV can lead to severe neurological complications.
Observation:
- CHIKV identified in an elderly woman in Brazil presenting with febrile illness and severe arthralgia.
- Electroneuromyography confirmed peripheral polyneuropathy in upper and lower limbs.
Findings:
- The patient's symptoms suggest a potential immune-mediated response involving T cells and inflammatory cytokines.
- Peripheral polyneuropathy is a significant neurological manifestation of CHIKV infection.
Implications:
- Highlights the emergence of CHIKV-related neuroinfections.
- Emphasizes the importance of early diagnosis of neurological alterations in CHIKV cases for effective clinical management.
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