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Updated: Jan 20, 2026

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Potential synaptic plasticity-based Shenzhiling oral liquid for a SAD Mouse Model.

Yahan Wang1,2, Pengwen Wang1,2, Fang Chen1,2,3

  • 1Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine (BUCM), Beijing, China.

Brain and Behavior
|August 21, 2019
PubMed
Summary

Shenzhiling (SZL) oral liquid improved memory in a mouse model of sporadic Alzheimer's disease (SAD). This traditional Chinese medicine may protect synaptic plasticity by modulating glutamate receptors and GSK3β, offering potential SAD treatment.

Keywords:
GSK3βShenzhiling oral liquidglutamate receptorssporadic Alzheimer's diseasesynapse

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Traditional Chinese Medicine

Background:

  • Synaptic plasticity underpins memory formation.
  • Abnormal glucose metabolism in sporadic Alzheimer's disease (SAD) may impair synaptic plasticity and cause memory deficits.
  • The precise mechanism by which Shenzhiling (SZL) oral liquid mitigates cognitive impairment in SAD via synaptic plasticity is not fully understood.

Purpose of the Study:

  • To investigate if SZL exerts a protective synaptic effect mediated by glutamate receptors and glycogen synthesis kinase 3β (GSK3β).
  • To determine if SZL can enhance cognitive function in a mouse model of SAD.

Main Methods:

  • A sporadic Alzheimer's disease (SAD) mouse model was established using streptozotocin (STZ) injection.
  • Mice were treated with SZL or artificial cerebrospinal fluid (control) for 3 months.
  • Behavioral tests (step-down test), Western blot, and immunohistochemistry were used to assess memory, synaptic plasticity markers (NMDAR2B, mGlu5), and GSK3β levels in the hippocampus.

Main Results:

  • SZL treatment significantly improved memory retention in SAD mice after 3 months.
  • Significant alterations in the expression levels of NMDAR2B, mGlu5, and GSK3β were observed in the hippocampus.
  • SZL modulated key proteins involved in synaptic function and plasticity.

Conclusions:

  • Shenzhiling (SZL) demonstrates potential therapeutic benefits for sporadic Alzheimer's disease (SAD).
  • SZL may alleviate cognitive impairment by enhancing synaptic plasticity through modulation of glutamate receptors and GSK3β.
  • This study supports the use of traditional Chinese medicine like SZL in managing SAD.