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Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
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Periodontal Medicine: 100 Years of Progress
J D Beck1, P N Papapanou2, K H Philips3
11 Department of Periodontology, University of North Carolina School of Dentistry, Chapel Hill, NC, USA.
Journal of Dental Research
|August 21, 2019
Summary
Periodontal medicine research shows links between gum disease and systemic conditions like cardiovascular disease, diabetes, and adverse pregnancy outcomes. However, treatment effectiveness for these systemic links remains inconsistent.
Area of Science:
- Oral health research
- Systemic disease links
- Periodontal medicine
Background:
- Periodontal medicine explores the impact of oral infections on overall health.
- Periodontitis is associated with over 50 systemic conditions.
- This review covers 100 years of research on periodontal medicine.
Observation:
- Focus on cardiovascular disease, diabetes mellitus, and adverse pregnancy outcomes.
- 29 seminal studies were selected for their novel observations and paradigm shifts.
- Studies were organized chronologically and by systemic condition.
Findings:
- Most studies indicate a positive association between poor periodontal status and systemic diseases.
- Associations are supported by systematic reviews.
- Randomized controlled trials on periodontal therapy's systemic effects yielded conflicting results.
Implications:
- Highlights the need for standardized periodontal disease definitions.
- Emphasizes understanding the periodontal phenotype relevant to systemic links.
- Suggests further research on comorbid conditions, participant selection, and intervention timing/intensity.
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