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The Development of an Antimicrobial Contact Lens - From the Laboratory to the Clinic
Mark D P Willcox1, R Chen2, P Kalaiselvan1
1School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
Abstract:
Contact lens wear is generally safe and provides excellent vision. However, contact lens wear is often associated with the risk of developing ocular surface infection and inflammation, and in severe cases, the infection can result in loss of vision. Antimicrobial peptide-coated contact lenses have been made to help reduce the incidence of infection and inflammation. This paper reviews the research progress from conception, through the laboratory and preclinical tests to the latest information on clinical testing of an antimicrobial contact lens. We provide insights into the pathways followed and pitfalls that have been encountered. The journey has not always been linear or smooth, but has resulted in some of the first published clinical testing of antimicrobial peptide-coated contact lenses in humans. We hope this may help lead to the development and commercialisation of antimicrobial contact lenses in the future.
Insights
Antimicrobial peptide-coated contact lenses show promise for reducing eye infections and inflammation. Early clinical trials in humans are underway, aiming for future commercialization of these advanced contact lenses.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Infectious Diseases
Background:
- Contact lens wear is common but carries risks of ocular infection and inflammation.
- Severe infections can lead to vision loss.
- Antimicrobial coatings are being developed to mitigate these risks.
Purpose of the Study:
- To review the development of antimicrobial contact lenses.
- To discuss research progress from conception to clinical testing.
- To highlight challenges and successes in bringing antimicrobial contact lenses to market.
Main Methods:
- Review of research progress in antimicrobial contact lens development.
- Analysis of laboratory and preclinical testing data.
- Examination of findings from initial human clinical trials.
Main Results:
- Antimicrobial peptide-coated contact lenses have progressed through development stages.
- The research journey involved overcoming various obstacles.
- The first published clinical testing in humans has been achieved.
Conclusions:
- Antimicrobial contact lenses represent a significant advancement in eye care.
- Clinical testing indicates potential for reducing infection and inflammation.
- Further development may lead to commercial availability of safer contact lenses.
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