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Hepatitis C virus genotype affects survival in patients with hepatocellular carcinoma

Hye Kyong Park1, Sang Soo Lee2,3,4, Chang Bin Im1

  • 1Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.

BMC Cancer
|August 21, 2019
PubMed

Insights

Hepatitis C virus (HCV) genotype 2 is associated with improved survival in patients with liver cancer (HCC). This finding suggests genotype may influence treatment outcomes for HCV-related HCC.

Area of Science:

  • Hepatology
  • Virology
  • Oncology

Background:

  • Hepatocellular carcinoma (HCC) is a major complication of chronic hepatitis C virus (HCV) infection.
  • The impact of specific HCV genotypes on HCC patient survival remains unclear.
  • This study investigates the relationship between HCV genotype and survival in HCC patients.

Purpose of the Study:

  • To determine if hepatitis C virus (HCV) genotype influences survival rates in patients diagnosed with hepatocellular carcinoma (HCC).
  • To analyze survival differences based on HCV genotypes (1, 2, and 3) in a Korean cohort.
  • To identify independent prognostic factors for mortality in HCV-related HCC.

Main Methods:

  • Retrospective cohort study of 180 patients with HCV-related HCC from 2005-2016.
  • Propensity score matching was employed to minimize bias between genotype 2 and non-genotype 2 groups.
  • Multivariate Cox regression analysis was used to assess risk factors for death.

Main Results:

  • Patients with HCV genotype 2 demonstrated significantly longer median overall survival (31.7 months) compared to genotype 1 (28.7 months) and genotype 3 (15.0 months).
  • Genotype 2 was associated with improved decompensation-free survival.
  • No significant difference in recurrence-free survival was observed for patients undergoing curative treatment.

Conclusions:

  • Hepatitis C virus (HCV) genotype 2 is linked to better survival outcomes in patients with HCV-related hepatocellular carcinoma (HCC).
  • Non-genotype 2 is an independent risk factor for mortality in this patient population.
Abstract

Keywords:
GenotypeHepatitis C virusHepatocellular carcinomaSurvival

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