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Diurnal blood pressure loads are associated with lower cognitive performances in controlled-hypertensive elderly

Adrián Noriega de la Colina1,2, Rong Wu3, Laurence Desjardins-Crépeau1,4

  • 1Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal.

Journal of Hypertension
|August 21, 2019
PubMed

Insights

High blood pressure loads are linked to poorer cognitive function in older adults, even when controlled. This study found that higher diurnal blood pressure loads correlated with worse performance on memory and executive function tests in controlled hypertensive individuals.

Area of Science:

  • Neurology
  • Cardiology
  • Gerontology

Background:

  • Midlife hypertension is a known risk factor for cognitive decline.
  • Blood pressure (BP) loads in treated hypertensive individuals are linked to end-organ damage.

Purpose of the Study:

  • To investigate the correlation between BP load and cognitive performance in normotensive and controlled hypertensive (CHT) individuals aged 60-75.
  • To determine if BP load impacts cognitive flexibility, memory, and processing speed.

Main Methods:

  • Participants were divided into normotensive (n=49) and CHT (n=28) groups.
  • Ambulatory blood pressure monitoring and cognitive tests (Rey Auditory Verbal Learning Test, Trail Making Test, Color-Word Interference Test, Digit-Symbol Substitution) were used.

Main Results:

  • CHT participants showed lower performance on Rey Auditory Verbal Learning Test measures.
  • In CHT individuals, higher diurnal systolic BP loads correlated with poorer performance on Trail Making Test Part B, TMTB-TMT Part A, Color-Word Interference Test Switching Cost, and Digit-Symbol Substitution Score.
  • Diurnal diastolic BP loads were inversely correlated with TMTB and TMTB-TMT Part A in CHT.
  • In normotensive subjects, diurnal systolic BP loads were associated with delayed recall and digit span performance.

Conclusions:

  • Diurnal BP loads are associated with reduced cognitive performance in CHT individuals.
  • Findings suggest a potential benefit in lowering target diurnal BP levels and/or their variability to preserve cognitive function.
Abstract

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