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Up-regulation of RIP1 and IPS-1 in chronic HBV infected patients

Minoo Safari-Arababadi1, Mohammad Hossein Modarressi1,2, Mohammad Kazemi Arababadi3,4

  • 1Department of Genetics, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Genetics and Molecular Biology
|August 21, 2019
PubMed

Insights

Increased expression of IPS-1 and RIP1 in immune cells of chronic hepatitis B patients suggests their role in low-grade inflammation driving liver disease progression.

Area of Science:

  • Immunology
  • Virology
  • Hepatology

Background:

  • Intracytoplasmic receptors RIG1 and MDA5 recognize viral double-stranded RNA.
  • IPS-1 and RIP1 are key downstream signaling molecules in this innate immune pathway.

Purpose of the Study:

  • To investigate mRNA levels of IPS-1 and RIP1 in peripheral blood immune cells of chronic hepatitis B (CHB) patients.
  • To explore the relationship between IPS-1/RIP1 expression and CHB disease markers.

Main Methods:

  • Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used.
  • mRNA levels of IPS-1 and RIP1 were measured in 60 CHB patients and 120 healthy controls.

Main Results:

  • Significant elevation of IPS-1 and RIP1 mRNA levels was observed in CHB patients compared to healthy individuals.
  • No correlation was found between IPS-1/RIP1 expression and serum HBeAg levels or liver enzymes.

Conclusions:

  • IPS-1 and RIP1 may contribute to the chronic low-grade inflammation characteristic of CHB.
  • This inflammation is implicated in the pathogenesis of liver cirrhosis and hepatocellular carcinoma.

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