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Soluble E-cadherin is associated with oxidative stress in patients with chronic HBV infection

Jun Yang1, Yuan Xiong2, Lijing Zhou1

  • 1Department of Laboratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Journal of Medical Virology
|August 21, 2019
PubMed

Insights

Serum soluble E-cadherin (sE-cadherin) is elevated in chronic hepatitis B (CHB) patients, correlating with increased oxidative stress and liver damage. This suggests sE-cadherin may serve as a biomarker for CHB progression.

Area of Science:

  • Hepatology
  • Biochemistry
  • Immunology

Background:

  • Serum soluble E-cadherin (sE-cadherin) is implicated in physiological and pathological processes.
  • The relationship between sE-cadherin and oxidative stress in chronic hepatitis B (CHB) requires further elucidation.

Purpose of the Study:

  • To investigate the molecular mechanisms of sE-cadherin in CHB virus infection.
  • To explore the association between serum sE-cadherin levels and oxidative stress markers in CHB patients.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify serum sE-cadherin, total antioxidant capacity (TAC), glutathione (GSH), superoxide dismutase (SOD), total oxidant activity (TOA), NADPH oxidase 2 (NOX2), and malondialdehyde (MDA).
  • Measurements were performed on samples from 51 HBeAg-negative CHB patients, 54 HBeAg-positive CHB patients, and 109 healthy controls.

Main Results:

  • Patients with CHB exhibited significantly higher serum sE-cadherin levels compared to healthy individuals (P < .01).
  • Serum sE-cadherin levels showed a significant negative correlation with TAC, GSH, and SOD in CHB patients.
  • Serum sE-cadherin concentrations were significantly positively correlated with liver enzyme markers (ALT, AST) and oxidative stress markers (TOA, NOX2, MDA) in CHB patients.

Conclusions:

  • Serum sE-cadherin may serve as a novel biomarker for assessing inflammation and oxidative stress in the context of hepatitis B virus infection.
  • Elevated sE-cadherin is associated with an exacerbated oxidative stress state in CHB.
  • Understanding the role of sE-cadherin can aid in monitoring CHB progression and management.

Keywords:
NOX2chronic hepatitis Bhepatitis B virusoxidative stresssE-cadherin

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