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Investigation of a Common Clinical Approach to Poor Growth in Preterm Infants
Stephanie G Korff1, Julie Ross1, Kristen Morella2
1Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.
American Journal of Perinatology
|August 21, 2019
Summary
Supplementing very low birth weight infants with medium-chain triglyceride (MCT) oil or formula powder improved their growth velocity and weight z-score trajectory in the short term.
Area of Science:
- Neonatal nutrition
- Pediatric growth studies
- Clinical nutrition research
Background:
- Very low birth weight (VLBW) infants often require nutritional support to optimize growth.
- Human milk fortifiers are standard, but additional energy may enhance growth velocity.
- Medium-chain triglyceride (MCT) oil and formula powder are potential energy supplements.
Purpose of the Study:
- To evaluate the impact of elevated energy intake via MCT oil or formula powder on growth velocity and weight z-scores in VLBW infants.
- To compare the short-term effects of these two energy supplementation methods.
Main Methods:
- A cohort study design was employed.
- Infants received either MCT oil or formula powder for at least 7 days as an energy supplement.
- Growth velocity and weight z-scores were measured pre- and postintervention, focusing on 7-day changes.
Main Results:
- Forty-three VLBW infants were included in the study.
- Infants receiving MCT oil were more preterm with lower birth weights.
- A significant increase in growth velocity (10.0 to 19.8 g/kg/day) and weight z-score (-0.24 to 0.05) was observed postintervention.
Conclusions:
- Elevated energy intake using MCT oil or formula powder is associated with improved short-term growth velocity.
- This nutritional strategy positively impacts the weight z-score trajectory in VLBW infants.
- Further research may explore long-term outcomes of such interventions.
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