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Related Concept Videos

Gallbladder01:17

Gallbladder

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The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Diseases of the Liver and Gallbladder01:26

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group Therapy01:26

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Adjuvant therapy for resected gallbladder cancer.

Eiichiro Suzuki1, John Bridgewater2

  • 1UCL, Cancer Institute, London, UK; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Chinese Clinical Oncology
|August 22, 2019
PubMed
Summary

Adjuvant therapy, including chemotherapy and radiation, offers potential survival benefits for gallbladder cancer patients. Ongoing research explores novel treatments like immunotherapy and targeted therapies.

Keywords:
Gallbladder canceradjuvant therapycapecitabine

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Gallbladder cancer, a subset of biliary tract cancers, is associated with a poor prognosis.
  • Current adjuvant therapy options include radiotherapy, chemoradiation, and systemic chemotherapy, with limited high-level evidence.
  • Recent phase III trials highlight capecitabine as a standard treatment for biliary tract cancers, including gallbladder cancer.

Purpose of the Study:

  • To review the current landscape of adjuvant therapy for gallbladder cancer.
  • To discuss emerging treatment modalities and future directions in gallbladder cancer management.

Main Methods:

  • Literature review of retrospective studies and meta-analyses on adjuvant therapy for gallbladder cancer.
  • Summary of recent phase III trial findings, specifically regarding capecitabine.
  • Overview of ongoing research in chemotherapy, surgical strategies, immunotherapy, and molecular-targeted therapies.

Main Results:

  • Adjuvant therapies, including various combinations of radiation and chemotherapy, are explored for improving survival in gallbladder cancer.
  • Capecitabine has emerged as a standard treatment option based on recent phase III study data.
  • Active research is underway to investigate novel approaches such as immunotherapy and molecular profiling-guided targeted therapies.

Conclusions:

  • Adjuvant therapy plays a crucial role in potentially improving survival for gallbladder cancer patients.
  • The field is rapidly evolving with ongoing research into novel systemic therapies, surgical techniques, and personalized medicine approaches.
  • Future perspectives involve integrating these advancements to optimize gallbladder cancer treatment strategies.