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Updated: Jan 20, 2026

Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
Family cluster of multi-drug resistant tuberculosis in Kingdom of Saudi Arabia
Abeer N Alshukairi1, Hanan M Moalim1, Asim Alsaedi2
1Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Abstract:
We describe the clinical and genetic characteristics of multi-drug resistant tuberculosis (MDR-TB) in a family cluster in the western region of Kingdom of Saudi Arabia diagnosed between 2012 and 2016. All cases had risk factors for tuberculosis acquisition and they were not household contacts of the index case. Genetic analysis detected both MDR-TB and pre-extensively drug-resistant tuberculosis (pre-XDR TB) strains in the index case and confirmed tuberculosis transmission between two cases. Lack of early diagnosis of MDR-TB by molecular testing and lack of extended contact tracing contributed to the transmission of MDR-TB among this family cluster over four years.
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