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Effectiveness of various nonpharmacological analgesic methods in newborns
Pancham Kumar1, Rakesh Sharma1, Sukhdev Rathour1
1Department of Pediatrics, Indira Gandhi Medical College, Shimla, India.
Insights
Nonpharmacological methods like oral sucrose and nonnutritive sucking effectively reduce pain in newborns during immunizations. These simple interventions offer significant pain relief, improving infant comfort during vaccination.
Area of Science:
- Neonatal care
- Pain management
- Developmental pediatrics
Background:
- Infant pain during early development can negatively impact neurodevelopment.
- Neonatal immunizations, such as the hepatitis B vaccine (HBV), are a common source of pain for newborns.
- Effective pain management strategies are crucial for infant well-being.
Purpose of the Study:
- To compare the efficacy of various nonpharmacological pain relief methods in newborns.
- To inform the development of safe and effective analgesic approaches for neonates.
- To evaluate interventions for pain experienced during infant immunization.
Main Methods:
- A prospective study involving 300 healthy term neonates at a tertiary care hospital.
- Neonates were divided into six groups: five receiving nonpharmacological interventions (breastfeeding, nonnutritive sucking, rocking, 25% sucrose, distilled water) and one control group.
- Pain response was measured using cry duration and the Douleur Aigue Nveau-ne (DAN) score post-hepatitis B vaccine (HBV) injection.
Main Results:
- All intervention groups showed reduced cry duration compared to controls.
- Significantly shorter cry durations were observed in the 25% sucrose, breastfeeding, and nonnutritive sucking groups.
- The breastfeeding and 25% sucrose groups demonstrated significant reductions in DAN scores at multiple time points post-vaccination.
Conclusions:
- Oral sucrose and nonnutritive sucking are effective nonpharmacological methods for reducing neonatal pain.
- These simple interventions provide significant pain relief during infant procedures like vaccination.
- Further utilization of these underutilized methods is recommended for neonatal pain management.
Background:
Pain during the developmental period may adversely affect developing neuronal pathways and result in adverse neurodevelopmental, cognitive, and behavioral effects in later life. Immunizations, e.g., hepatitis B vaccine (HBV), administered at birth are painful experiences to which neonates are universally subjected.
Purpose:
Here we aimed to study and compare the effectiveness of various nonpharmacological pain management methods in newborns to enable the development of safe and effective analgesic methods for newborns.
Methods:
This prospective study was conducted at a tertiary care hospital in the Himalayan region. Three hundred term healthy neonates were divided into 6 groups of 50 each. Groups 1-5 were intervention groups, patients of which received a nonpharmacological intervention (breastfeeding, nonnutritive sucking, rocking, 25% sucrose, or distilled water) before the intramuscular HBV, while patients in group 6 received no intervention. The pain response in each group after the HBV injection was assessed and compared using cry duration and Douleur Aigue Nveau-ne (DAN) score, a behavioral acute pain rating scale for newborns.
Results:
Cry duration was decreased in all intervention groups, significantly so in the sucrose (19.90 seconds), breastfeeding (31.57 seconds), and nonnutritive sucking (36.93 seconds) groups compared with controls (52.86 seconds). DAN scores decreased significantly (P<0.05) at one or more points i.e. 30, 60, or 120 seconds in the breastfeeding and 25% sucrose intervention groups compared with controls.
Conclusion:
Oral sucrose and nonnutritive sucking are simple yet underutilized nonpharmacological interventions that effectively reduce pain in newborns.
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