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Rare Event Detection Using Error-corrected DNA and RNA Sequencing
Published on: August 3, 2018
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Local Dependence in Latent Class Analysis of Rare and Sensitive Events
Marcus E Berzofsky1, Paul P Biemer1,2, William D Kalsbeek2
1RTI International, Research Triangle Park, NC, USA.
Summary
Latent class analysis (LCA) helps survey researchers assess measurement error and bias. This study proposes a modeling strategy to address local dependence, a key threat to LCA validity, improving estimate accuracy.
Area of Science:
- Survey Methodology
- Statistical Modeling
- Psychometrics
Background:
- Latent class analysis (LCA) is crucial for survey methodologists to assess measurement error, evaluate survey methods, and estimate population prevalence bias.
- LCA is applicable when gold-standard measurements are unavailable, provided indicators meet identifiability criteria.
- Model validity in LCA is threatened by local dependence, stemming from bivocality, behaviorally correlated error, or latent heterogeneity.
Purpose of the Study:
- To examine threats to local independence in LCA, including bivocality, behaviorally correlated error, and latent heterogeneity.
- To provide insights into questionnaire designs that minimize local dependence.
- To explore modeling strategies for mitigating the effects of local dependence on statistical inference, particularly for rare and sensitive outcomes.
Main Methods:
- Investigated three potential causes of local dependence: bivocality, behaviorally correlated error, and latent heterogeneity.
- Focused on developing and testing a practical approach for diagnosing and mitigating model failures in LCA.
- Empirically tested the proposed modeling strategy using real-world data from a national survey on inmate sexual abuse, where measurement errors are a significant concern.
Main Results:
- The proposed modeling strategy demonstrated success in reducing local dependence bias in estimates.
- The effectiveness of the strategy varied based on the quality of indicators used in the analysis.
- Even with the proposed strategy, local dependence bias could not always be reduced to acceptable levels when using only three indicators.
Conclusions:
- The developed modeling strategy is effective in mitigating local dependence bias in latent class analysis, particularly for sensitive survey data.
- Indicator quality is a critical factor influencing the success of bias reduction techniques in LCA.
- While the strategy improves accuracy, careful consideration of indicator selection and model diagnostics is essential for reliable survey estimates.
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