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Eye-of-the-tiger Sign in Neurodegeneration with Brain Iron Accumulation
Madeline Goldberg1, Khizar Malik2, Rekha Jiswant1
1Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.
Abstract:
A 68-year-old male patient presented to the neurology clinic with tremor, lightheadedness, and a history of syncope. Exam showed mild Parkinsonism. Neuroimaging revealed symmetric lesions of the globus pallidus (the eye-of-the-tiger sign) concerning for neurodegeneration with brain iron accumulation (NBIA). Genetic panel for NBIA was ordered, specifically pantothenate kinase-associated neurodegeneration (PKAN), including pantothenate kinase 2 (PanK2) - the genetic marker for the pantothenate kinase enzyme.
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