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Data from quantitative serum proteomic analysis after laparoscopic gastric plication.

Parisa Savedoroudi1,2, Tue Bjerg Bennike2, Kenneth Kastaniegaard2

  • 1Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran.

Data in Brief
|August 22, 2019
PubMed
Summary

Laparoscopic Gastric Plication (LGP) alters the serum proteome in morbidly obese patients, aiding weight loss and improving metabolic health. This study used proteomics to identify key protein changes after bariatric surgery.

Keywords:
Bariatric surgeryLaparoscopic gastric plicationObesityProteomics

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Area of Science:

  • Biochemistry
  • Proteomics
  • Metabolic Syndrome Research

Background:

  • Morbid obesity is a significant health concern linked to metabolic syndrome.
  • Bariatric surgery, including Laparoscopic Gastric Plication (LGP), offers effective weight loss and metabolic improvements.
  • Understanding proteomic changes post-surgery can elucidate mechanisms of action.

Purpose of the Study:

  • To analyze serum proteome alterations in morbidly obese patients following Laparoscopic Gastric Plication (LGP).
  • To identify differentially abundant proteins and their associated biological pathways pre- and post-LGP surgery.
  • To provide insights into the molecular mechanisms underlying LGP's efficacy.

Main Methods:

  • Label-free quantitative shotgun proteomics applied to serum samples.
  • Comparison of proteomes from pre-surgery, 1-2 months post-surgery (T1), and 4-5 months post-surgery (T2).
  • Utilized WebGestalt for Gene Ontology analysis and Ingenuity Pathway Analysis (IPA) for network analysis.

Main Results:

  • Quantified 224 proteins with significant changes between pre- and post-surgery states.
  • Identified differentially regulated proteins involved in key biological processes and molecular functions.
  • Revealed molecular networks associated with altered protein abundance post-LGP.

Conclusions:

  • Laparoscopic Gastric Plication induces significant changes in the serum proteome.
  • These proteomic shifts correlate with weight loss and metabolic improvements in obese patients.
  • Proteomics provides a valuable tool for understanding bariatric surgery outcomes.