Related Experiment Video

Updated: Jan 20, 2026

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.3K

Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR

Lanfeng Zhang1, Xingyu Tao1, Qiaofen Fu2

  • 1Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510315, P.R. China.

Oncology Reports
|August 22, 2019
PubMed

Insights

Curcumin, a natural compound, effectively inhibits non-small cell lung cancer (NSCLC) proliferation and metastasis. It targets cell cycle and epithelial-mesenchymal transition pathways, offering a potential new treatment for NSCLC.

Area of Science:

  • Oncology
  • Natural Products Chemistry
  • Molecular Biology

Background:

  • Non-small cell lung cancer (NSCLC) has a poor prognosis despite available treatments.
  • Treatment side effects and accessibility are significant challenges in NSCLC therapy.
  • Curcumin, derived from Zingiberaceae plants, shows potential antitumor properties.

Purpose of the Study:

  • To investigate the efficacy and mechanisms of curcumin in inhibiting NSCLC progression.
  • To explore curcumin's effects on cell proliferation, cell cycle, and migration in NSCLC.
  • To elucidate the molecular pathways targeted by curcumin in NSCLC.

Main Methods:

  • In vitro assays including MTS, colony formation, flow cytometry, and Transwell migration.
  • Western blotting to analyze protein expression.
  • Analysis of clinical NSCLC specimens.

Main Results:

  • Curcumin inhibited NSCLC cell proliferation, cell cycle transition (G2/M arrest), and migration.
  • Curcumin suppressed the expression of Toll-like receptor 4 (TLR4)/MyD88 and EGFR.
  • High expression of TLR4 and MyD88 was observed in NSCLC tissues, correlating positively.

Conclusions:

  • Curcumin demonstrates significant antitumor activity against NSCLC by targeting cell cycle and epithelial-mesenchymal transition.
  • The EGFR and TLR4/MyD88 pathways are implicated in curcumin's anti-NSCLC effects.
  • Curcumin presents a promising, natural therapeutic agent for NSCLC treatment.

More Related Videos

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

4.6K
In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines09:57

In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines

Published on: March 5, 2019

10.7K

Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
56.9K
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.4K
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.7K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
C4 Pathway and CAM01:27

C4 Pathway and CAM

Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
48.8K