Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

487
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
487
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.2K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

850
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
850
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

2.8K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
2.8K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.7K
The pathophysiology of pneumonia involves the following steps:
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stated patient preferences for overnight at-home diagnostic assessment of sleep disorders.

Sleep & breathing = Schlaf & Atmung·2024
Same author

Patient-reported experience with hypoglossal nerve stimulation in the treatment of obstructive sleep apnea.

Sleep & breathing = Schlaf & Atmung·2023
Same author

Diagnosis and treatment of isolated snoring-open questions and areas for future research.

Sleep & breathing = Schlaf & Atmung·2020
Same author

[Medical examination: Preparation for ENT specialisation : Part 46].

HNO·2020
Same author

[New diagnostic and therapeutic approaches in obstructive sleep apnea].

HNO·2019
Same author

[Sleep position trainers for treatment of supine obstructive sleep apnea : A comparison of two different training modalities].

HNO·2019

Related Experiment Video

Updated: Jan 20, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.5K

[Pathophysiology of obstructive sleep apnea].

C Heiser1, D Eckert2

  • 1Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland. hno@heiser-online.com.

HNO
|August 22, 2019
PubMed
Summary

Obstructive sleep apnea (OSA) is common, but its causes are not fully understood. Research is exploring non-anatomical factors like respiratory control and upper airway muscles to improve patient treatments.

Keywords:
ArousalLoop gainRespiratory driveSleep-disordered breathing disordersUpper airway

More Related Videos

Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.1K
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.4K

Related Experiment Videos

Last Updated: Jan 20, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.5K
Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.1K
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.4K

Area of Science:

  • Sleep Medicine
  • Respiratory Physiology

Background:

  • Obstructive sleep apnea (OSA) has a high prevalence in industrialized nations.
  • Current treatments for OSA are limited, and its pathophysiology remains largely unexplained by anatomical factors alone.

Purpose of the Study:

  • To explore non-anatomical factors contributing to OSA development.
  • To understand individual pathophysiological processes for personalized treatment strategies.

Main Methods:

  • Review of recent findings on non-anatomical OSA factors.
  • Analysis of respiratory excitation threshold (arousals) and respiratory drive (loop gain).
  • Evaluation of upper airway dilator muscle control and function.

Main Results:

  • Non-anatomical factors significantly influence OSA development.
  • Key factors include arousal thresholds, loop gain, and upper airway muscle dynamics.

Conclusions:

  • Understanding individual pathophysiological mechanisms is crucial for advancing OSA treatment.
  • Future research should focus on these non-anatomical factors to develop tailored therapies for OSA patients.