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Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
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Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

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Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur

Javier Esteban Mussin1, María Virginia Roldán2, Florencia Rojas3

  • 1Mycology Department, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Av. Las Heras 727, 3500, Resistencia, Chaco, Argentina. javiermussin@hotmail.com.

AMB Express
|August 22, 2019
PubMed

Insights

Silver nanoparticles (AgNP) demonstrate potent antifungal activity against Malassezia furfur, a common skin microbe. Combining AgNP with ketoconazole (KTZ) in a topical gel offers a promising new treatment for superficial malasseziosis.

Area of Science:

  • Mycology
  • Nanotechnology
  • Dermatology

Background:

  • Malassezia furfur is a lipophilic yeast residing on human skin, implicated in various dermatological conditions.
  • Nanotechnology offers novel approaches for antimicrobial drug development, particularly for skin infections.

Purpose of the Study:

  • To investigate the in vitro antifungal activity of silver nanoparticles (AgNP) against Malassezia furfur.
  • To assess the synergistic effects of AgNP with ketoconazole (KTZ) and formulate a combined antimicrobial gel.

Main Methods:

  • In vitro testing of AgNP against 41 clinical isolates of M. furfur.
  • Microscopic visualization of AgNP-Malassezia interaction.
  • Evaluation of AgNP-KTZ synergism and formulation of a carbopol-based gel.

Main Results:

  • Synthesized AgNP exhibited fungicidal action against M. furfur with low minimal inhibitory concentrations.
  • AgNP showed no antagonistic effects when combined with KTZ.
  • The AgNP-KTZ gel demonstrated potential for sustained release and improved topical therapy.

Conclusions:

  • AgNP possess broad-spectrum antimicrobial properties and fungicidal action suitable for skin infections.
  • A novel AgNP-KTZ carbopol gel formulation shows promise for enhanced topical treatment of superficial malasseziosis, potentially reducing application frequency and preventing recurrence.
Keywords:
Antifungal activityMalasseziaNanoparticlesSynergy

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