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MR imaging of neuronal migrational disorders
R E Osborn1, S E Byrd, T P Naidich
1Department of Radiology, Children's Memorial Hospital, Northwestern University Medical School, Chicago, IL 60614.
AJNR. American Journal of Neuroradiology
|November 1, 1988
Summary
Magnetic Resonance (MR) imaging effectively diagnoses brain neuronal migrational disorders, including lissencephaly and schizencephaly. This study highlights MR as the preferred imaging method for these developmental anomalies.
Area of Science:
- Neuroscience
- Radiology
- Developmental Biology
Background:
- Neuronal migrational disorders are brain malformations due to abnormal neuroblast migration.
- These include conditions like lissencephaly, pachygyria, schizencephaly, heterotopias, hemimegalencephaly, and polymicrogyria.
Purpose of the Study:
- To evaluate the efficacy of Magnetic Resonance (MR) imaging in diagnosing various neuronal migrational disorders.
- To determine the optimal MR imaging sequences and planes for visualizing these anomalies.
Main Methods:
- MR imaging was performed on 21 patients with confirmed neuronal migratory anomalies using 0.5-T or 1.5-T scanners.
- T1-weighted spin-echo sequences were used for all patients; inversion-recovery sequences were added for seven.
- Axial and coronal planes were utilized for imaging.
Main Results:
- MR imaging successfully visualized migrational anomalies in patients with lissencephaly, pachygyria, schizencephaly, heterotopias, and hemimegalencephaly.
- Inversion-recovery sequences provided superior visualization of the cortical surface, cortex, and gray-white matter interface compared to spin-echo sequences alone.
- Both axial and coronal projections effectively demonstrated the abnormalities.
Conclusions:
- MR imaging is an excellent modality for diagnosing a spectrum of neuronal migrational disorders.
- It is considered the imaging method of choice for evaluating these congenital brain malformations.