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AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
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Misleading CT perfusion in subacute ischemic stroke.

Houman Sotoudeh1, Omid Shafaat2, Ehsan Sotoudeh3

  • 1Department of Neuroradiology and Neurology, University of Alabama at Birmingham (UAB), JTN 333, 619 19th St S, Birmingham, AL, 35294, USA. hsotoudeh@uabmc.edu.

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PubMed
Summary

Computed tomography perfusion (CTP) software RAPID© can mislead stroke diagnosis in subacute infarction. Diffusion-weighted imaging magnetic resonance imaging (DWI-MRI) is recommended for accurate infarction assessment.

Keywords:
Computed tomography perfusionIschemic strokeSoftware

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Computed tomography perfusion (CTP) software, particularly RAPID©, is widely utilized in stroke centers for ischemic stroke assessment.
  • This software is crucial for determining infarct and ischemic penumbra volumes, guiding treatment planning for stroke patients.

Observation:

  • This study highlights two cases where RAPID© software provided misleading CTP results in patients with subacute infarction.
  • The findings suggest a potential underdiagnosis of this pitfall due to the software's prevalent use and expanding application in subacute stroke.

Findings:

  • Misleading CTP interpretations by RAPID© software can occur in the subacute phase of infarction.
  • This diagnostic challenge may lead to inappropriate patient management if not identified.

Implications:

  • Accurate assessment of infarction in the subacute phase is critical for effective stroke management.
  • Diffusion-weighted imaging magnetic resonance imaging (DWI-MRI) is proposed as a more reliable method for estimating infarction in this clinical scenario.
  • Awareness of CTP software limitations is essential for clinicians to prevent potential misdiagnosis and ensure optimal patient outcomes.