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Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first

Recai Türkoğlu1, Gülçin Benbir2, Selen Özyurt2

  • 1Department of Neurology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.

International Ophthalmology
|August 22, 2019
PubMed
Abstract

Insights

Multiple sclerosis patients with optic neuritis onset show better executive functions and sleep quality, though with increased daytime sleepiness. Lower orexin-A and melatonin levels may contribute to these effects.

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Sleep Medicine

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • The initial clinical presentation of MS can influence disease progression.
  • Optic neuritis as a first event in MS has been linked to a milder course.

Purpose of the Study:

  • To investigate how the first clinical event in MS impacts cognitive function and sleep disturbances.
  • To explore the relationship between optic neuritis history and cognitive/sleep outcomes in MS patients.

Main Methods:

  • Recruited 26 MS patients, including 10 with optic neuritis as their first event.
  • Conducted comprehensive sleep studies and cognitive/motor performance tests.
  • Measured serum orexin-A and melatonin levels; assessed sleep quality and daytime sleepiness.

Main Results:

  • Optic neuritis onset/history correlated with increased daytime sleepiness, better sleep efficiency, longer NREM duration, and reduced wake time.
  • Patients with optic neuritis history scored better on executive function and attention tests.
  • Lower melatonin and orexin-A levels were observed in patients with optic neuritis onset.

Conclusions:

  • A history of optic neuritis in MS is associated with improved sleep quality and cognitive executive functions.
  • Increased daytime sleepiness is also a feature in MS patients with optic neuritis history.
  • Reduced orexin-A and melatonin levels may be a contributing factor to these observed effects.
Keywords:
AutoimmunityCognitiveMelatoninMultiple sclerosisOptic neuritisSleep

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