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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
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The Human Brain Proteome Project: Biological and Technological Challenges.

Joaquín Fernández-Irigoyen1, Fernando Corrales2, Enrique Santamaría3

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Neuroproteomics uses mass spectrometry to map the human brain

Keywords:
Human brainMass spectrometryProteomics

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Area of Science:

  • Neuroscience
  • Proteomics
  • Biomarker Discovery

Background:

  • Brain proteomics offers insights into neuropathophysiology.
  • Mass spectrometry-based neuroproteomics profiles neural proteomes.
  • The Human Brain Proteome Project (HBPP) maps the human brain's protein catalog.

Observation:

  • The biology- and disease-oriented HBPP (B/D-HBPP) focuses on spatiotemporal proteomic characterizations.
  • Research investigates mouse models of neurodegenerative diseases.
  • Proteostatic networks in dementia and clinical phenotypes are being elucidated.

Findings:

  • Neuroproteomics identifies potential cerebrospinal fluid (CSF) biomarkers.
  • Technological and computational innovations are emerging in neurobiology.
  • Novel biomarker candidates for neurodegenerative diseases have been discovered.

Implications:

  • Advances in neuroproteomics aid in understanding neurodegenerative diseases.
  • Discovering CSF biomarkers facilitates early disease detection.
  • This research contributes to mapping the human brain proteome and developing diagnostics.