Cyclosporine-induced renal macroangiopathy

Although nephrotoxicity secondary to cyclosporine (CsA) is common and has a predilection for arterioles, stenosis of the major renal artery or its primary branches has not yet been described as a manifestation of CsA toxicity. A case of a primary cadaveric renal transplant recipient treated with CsA who developed significant deterioration of renal function associated with angiographic evidence of high-grade stenosis of all three major branches of the renal artery that resolved completely after discontinuation of the drug is reported.