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Association of Vitamin D with Inflammatory Bowel Disease Activity in Pediatric Patients
Seoyoung Kim1, Yunkoo Kang2, Sowon Park1
1Pediatric Gastroenterology, Hepatology and Nutrition, Severance Pediatric IBD Research Group, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
Insights
Low vitamin D levels (serum 25[OH]D) are common in pediatric inflammatory bowel disease (IBD). Monitoring and supplementation are crucial, especially during active disease and in winter/spring.
Area of Science:
- Pediatric Gastroenterology
- Nutritional Immunology
- Inflammatory Bowel Disease Research
Background:
- Vitamin D levels (serum 25[OH]D) are known to correlate with inflammatory bowel disease (IBD).
- Understanding these correlations is vital for managing pediatric IBD patients.
Purpose of the Study:
- To investigate changes in serum 25[OH]D in pediatric IBD patients.
- To analyze the relationship between serum 25[OH]D and disease activity in children and adolescents with IBD.
Main Methods:
- Retrospective study of 96 pediatric IBD patients.
- Collected serologic inflammatory markers and clinical disease activity scores.
- Analyzed correlations between serum 25[OH]D and disease activity, including seasonal variations.
Main Results:
- 80.2% of patients had vitamin D deficiency (< 20 ng/mL) at diagnosis.
- Serum 25[OH]D was significantly higher in patients in remission compared to those with active disease (P < 0.001).
- Seasonal variations in serum 25[OH]D were observed during active disease but not in remission.
Conclusions:
- Serum 25[OH]D is inversely correlated with disease activity in pediatric IBD.
- Monitoring and vitamin D supplementation are recommended for active disease, particularly during winter and spring.
- Findings highlight the importance of vitamin D status in the management of pediatric IBD.
Background:
It has been known that vitamin D level (serum 25[OH]D) has correlation with inflammatory bowel disease (IBD). The purpose of this study is to investigate changes of serum 25[OH]D in pediatric IBD patients according to the disease activity.
Methods:
A total of 96 children and adolescent with IBD were enrolled in this retrospective study. Serologic inflammatory markers and clinical disease activity scores of the patients were collected, and their correlations with serum 25[OH]D were analyzed. Seasonal variations of serum 25[OH]D were also investigated both in active disease state and remission state.
Results:
Of the 96 patients, 41 (43%) were women and patients with a vitamin D deficiency (< 20 ng/mL) at diagnosis were 77 (80.2%). There was no significant difference between Crohn's disease and ulcerative colitis for serum 25[OH]D. Serum 25[OH]D was higher in remission group than in active disease group (12.4 [8.8-29] ng/mL vs. 17.9 [12.3-34.4] ng/mL; P < 0.001) and the difference was more significant than other micronutrients. There was no significant difference in serum 25[OH]D concentration between patients with ileal involvement and patients without ileal involvement. There were seasonal variations in the active phase, but there was no significant difference by season in the remission phase.
Conclusion:
Serum 25[OH]D is inversely correlated with disease activity in IBD. Monitoring and supplementation is required especially for active disease status and in winter and spring season.
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