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A quadrupole ion trap mass spectrometer for dry microparticle analysis.

Abdil Özdemir1, Jung-Lee Lin2, Mustafa Gülfen1

  • 1Department of Chemistry, Faculty of Arts and Sciences, Sakarya University, 54187 Esentepe, Sakarya, Turkey. abdilo@sakarya.edu.tr.

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We developed a rapid quadrupole ion trap mass spectrometer (QIT-MS) for analyzing micro-sized particles and cells. This new method accurately measures particle mass, offering broad applications in biological and inorganic sample analysis.

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Area of Science:

  • Analytical Chemistry
  • Biophysics
  • Mass Spectrometry

Background:

  • Accurate mass determination of micro-sized particles is crucial for various scientific disciplines.
  • Existing methods for micro-particle mass analysis can be time-consuming and limited in scope.
  • Charge detection quadrupole ion trap mass spectrometry (QIT-MS) offers potential for rapid, high-mass measurements.

Purpose of the Study:

  • To introduce a novel QIT-MS design for analyzing micro-sized inorganic and biological particles.
  • To establish a fast and accurate method for online mass measurement of microparticles.
  • To demonstrate the system's capability in analyzing cells, including red blood cells (RBCs) and MCF-7 breast cancer cells.

Main Methods:

  • A new charge detection quadrupole ion trap mass spectrometer (QIT-MS) was designed and implemented.
  • The QIT-MS system was calibrated using polystyrene (PS) particles ranging from 2 to 15 μm.
  • Masses of micro-sized dry inorganic particles, RBCs, and MCF-7 cells were measured.
  • Mass distribution profiles were generated using histogram analysis and fitted with Gaussian distributions.

Main Results:

  • The developed QIT-MS system enables online analysis of micro-sized particles up to 1 × 1017 Da.
  • Measured masses for RBCs were approximately 1.8 × 1013 Da.
  • MCF-7 cancer cell masses ranged from 1 × 1014 to 4 × 1014 Da.
  • The method demonstrated high speed and accuracy in particle mass determination.

Conclusions:

  • The novel QIT-MS design provides a rapid and effective tool for micro-particle mass spectrometry.
  • This technique shows significant promise for the analysis of diverse micro-sized samples, including biological cells.
  • The broad applicability of this method opens new avenues for research in particle analysis.