Bioceramic cement in the filling of bone defects in rats

To evaluate PBS®MCIMMO cement in the filling of bone defects.

Thirty-six adult male Wistar rats were divided into three groups of twelve individuals each (group 1, group 2 and group 3). In all groups, a bone failure in the femur was induced, 2.0 mm wide and 7.0 mm deep. In group 1, the PBS®MCIMMO cement was applied to the bone defect produced and a titanium implant (CONNECTION®) 1.5 mm thick and 6 mm long was installed. In group 2, only the PBS® CIMMO cement was installed. In group 3, only bone failure was performed. Kruskal Wallis tests were performed to compare the mean area among the three groups.

In all comparisons, significance was observed for group 2 (p = 0.0014-0.0026).

The PBS®CIMMO cement induced bone neoformation, and integration between the newly formed bone, cement, and implant was observed.