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EK-DRD: A Comprehensive Database for Drug Repositioning Inspired by Experimental Knowledge.

Chongze Zhao1, Xi Dai1, Yecheng Li1

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A new database, the Experimental Knowledge-Based Drug Repositioning Database (EK-DRD), systematically collects validated drug repositioning data. This resource aids researchers in discovering new therapeutic uses for existing drugs, accelerating drug development.

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Area of Science:

  • Pharmacology
  • Bioinformatics
  • Drug Discovery

Background:

  • Drug repositioning accelerates therapeutic development by repurposing approved drugs, reducing costs and risks.
  • A lack of comprehensive, systematic resources hinders the identification of drug repositioning opportunities.
  • Existing information on drug repositioning is vast and unsystematic, requiring a centralized database.

Purpose of the Study:

  • To develop a comprehensive database for experimentally validated drug repositioning information.
  • To create a centralized resource supporting scientists in drug repositioning research.
  • To facilitate the discovery of new indications for existing drugs.

Main Methods:

  • Utilized text and data mining combined with manual curation to build the database.
  • Integrated experimental data from target assays, cell assays, organism assays, and clinical trials.
  • Developed a web-based platform for searching and visualizing drug repositioning data.

Main Results:

  • The Experimental Knowledge-Based Drug Repositioning Database (EK-DRD) contains data for 1861 approved and 102 withdrawn drugs.
  • Annotation includes 30,944 target assay records, 3,999 cell assay records, 585 organism assay records, and 8,889 clinical trial records.
  • The database links drugs to 1,799 protein/target sequences, 856 diseases, and 1,332 pathways, with network visualization capabilities.

Conclusions:

  • EK-DRD provides a valuable, searchable resource for drug repositioning research.
  • The database enables exploration of relationships between drugs, targets, and diseases.
  • Freely accessible EK-DRD supports systematic drug repositioning efforts and accelerates drug discovery.