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Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
Published on: December 4, 2017
9.4K
Physiology of cerebrospinal fluid circulation.
Jonathan Shapey1,2, A Toma2, S R Saeed2,3,4
1Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London.
Current Opinion in Otolaryngology & Head and Neck Surgery
|August 22, 2019
Summary
Cerebrospinal fluid (CSF) physiology involves complex secretion, circulation, and resorption processes. Understanding these dynamics, including the glymphatic system, is crucial for brain development and function.
Area of Science:
- Neuroscience
- Physiology
- Biochemistry
Background:
- Cerebrospinal fluid (CSF) is vital for brain homeostasis.
- Its production, flow, and absorption are complex physiological processes.
Purpose of the Study:
- To review current evidence and new concepts in CSF physiology.
- To examine CSF secretion, circulation, and resorption.
- To highlight pathophysiological associations, particularly with intracranial pressure.
Main Methods:
- Review of current scientific literature and evidence.
- Synthesis of new concepts in CSF physiology.
- Analysis of pathophysiological relationships.
Main Results:
- CSF secretion primarily occurs via the choroid plexus, with Aquaporins playing a newly discovered role.
- CSF circulation involves the dynamic perivascular 'Glymphatic system'.
- Extraarachnoidal pathways represent novel concepts in CSF resorption.
Conclusions:
- CSF physiology is a multifactorial process essential for normal brain development and function.
- Interacting factors govern CSF dynamics and intracranial pressure regulation.
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