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Stimulation Location Determination using a 3D Digitizer with High-Definition Transcranial Direct Current Stimulation
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High-definition transcranial direct current stimulation in anorexia nervosa: A pilot study
Andrea Phillipou1,2,3,4, Melissa Kirkovski5, David J Castle2,3
1Centre for Mental Health, Swinburne University of Technology, Melbourne, Victoria, Australia.
The International Journal of Eating Disorders
|August 22, 2019
Summary
This study investigates the feasibility of using high-definition transcranial direct current stimulation (HD-tDCS) to non-invasively stimulate the inferior parietal lobe (IPL) in individuals with anorexia nervosa (AN). The findings will assess the safety and tolerability of this novel brain stimulation approach for AN treatment.
Area of Science:
- Neuroscience
- Psychiatry
Background:
- Anorexia nervosa (AN) is a severe psychiatric disorder with limited treatment options.
- Neurobiological underpinnings of AN are not fully understood, hindering development of targeted therapies.
- The inferior parietal lobe (IPL) has emerged as a potential neurobiological target for AN treatment.
Purpose of the Study:
- To investigate the feasibility and acceptability of non-invasive brain stimulation targeting the left inferior parietal lobe (IPL) in individuals with anorexia nervosa (AN).
- To evaluate the safety and tolerability of high-definition transcranial direct current stimulation (HD-tDCS) as a potential therapeutic intervention for AN.
Main Methods:
- A randomized, sham-controlled pilot study involving 20 participants with AN.
- Participants will receive 10 daily sessions of active or sham high-definition transcranial direct current stimulation (HD-tDCS).
- Assessments will be conducted at baseline, post-intervention, and at 4- and 12-week follow-ups.
Main Results:
- This section is not applicable as the study is a pilot investigation focused on feasibility and acceptability.
- Primary outcomes will focus on recruitment rates, adherence, and adverse events.
- Secondary outcomes will assess changes in relevant clinical and neurobiological measures.
Conclusions:
- This pilot study aims to establish the feasibility and acceptability of using HD-tDCS to modulate the IPL in individuals with AN.
- Successful demonstration of feasibility could pave the way for larger trials investigating the efficacy of this novel neuromodulation technique for AN.
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