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Published on: September 6, 2019
Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4H-pyran-3,5-dicarbonitrile Derivatives
Mo Zhang1, Meng-Nan Chen1, Jiao-Mian Li1
1National Demonstration Center for Experimental Chemistry Education, Hebei Key Laboratory of Organic Functional Molecules, College of Chemistry and Material Science , Hebei Normal University , No. 20 South Second Ring East Road , Shijiazhuang 050024 , P. R. China.
Abstract:
A novel approach for the visible-light-initiated synthesis of 2-amino-4H-pyran-3,5-dicarbonitrile derivatives via a one-pot, three-component reaction of aldehydes or isatins, malononitrile, and α-cyano ketones has been developed. The reaction was carried out at room temperature in ethanol/water to give the corresponding products with a wide range of functional groups in high yields. This process did not require any additives or chromatographic separation and could be applied for gram-scale synthesis.
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