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Related Experiment Video

Updated: Jan 20, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

Prostate Biopsy Processing.

Paari Murugan¹, Dip Shukla², Jennifer Morocho³

¹Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

American Journal of Clinical Pathology

|August 22, 2019

Summary

The BxChip method significantly reduces prostate biopsy processing time and tissue fragmentation. This innovative approach enhances diagnostic efficiency and offers cost savings for prostate cancer diagnosis.

Keywords:

Genitourinary pathology Multiplex tissue processing Prostate biopsy processing Technique

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Last Updated: Jan 20, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

Area of Science:

Uropathology
Biomedical Engineering
Cancer Diagnostics

Background:

Current prostate biopsy processing is inefficient and leads to tissue loss, impacting cancer diagnosis.
Standard methods are uneconomical and cumbersome for handling multiple biopsy cores.

Purpose of the Study:

To evaluate an alternative method for processing prostate biopsy cores.
To improve the efficiency and accuracy of prostate cancer diagnosis.

Main Methods:

Ex vivo processing of sextant prostate biopsy specimens from 48 prostates.
Comparison of standard processing with the BxChip, a biomimetic matrix for multiplexed core accommodation.
Evaluation of parameters including time, tissue length, and fragmentation.

Main Results:

The BxChip method reduced preanalytical and analytical time by over threefold.
Nonlinear tissue fragmentation was eliminated with the BxChip, unlike standard processing.
Significant increases in tissue length were observed.

Conclusions:

The BxChip technology minimizes tissue fragmentation in prostate biopsies.
This method enhances the efficiency of prostate cancer diagnosis.
BxChip offers cost savings and improved tissue handling for pathological analysis.