Related Experiment Video

Updated: Jun 22, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Subjective cognitive complaints in patients with Parkinson's disease

Pernille Louise Kjeldsen1,2, Malene Flensborg Damholdt1,3

  • 1Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Acta Neurologica Scandinavica
|August 22, 2019
PubMed

Insights

Subjective cognitive complaints are crucial for diagnosing Parkinson's disease mild cognitive impairment (PD-MCI). However, current research lacks standardized methods for measuring these complaints, hindering consistent diagnosis.

Area of Science:

  • Neurology
  • Neuroscience
  • Cognitive Science

Background:

  • Mild cognitive impairment (MCI) is highly prevalent in Parkinson's disease (PD), impacting nearly all patients.
  • Subjective cognitive complaints in PD patients indicate an elevated risk for developing PD-MCI.
  • The Movement Disorders Society (MDS) 2012 criteria mandate subjective cognitive complaints alongside objective impairment for PD-MCI diagnosis.

Purpose of the Study:

  • To review how subjective cognitive complaints are operationalized in empirical literature for Parkinson's disease mild cognitive impairment (PD-MCI).
  • To assess the association between subjective cognitive complaints and the level of cognitive impairment in PD patients.
  • To highlight the need for standardized measurement of subjective cognitive complaints in PD-MCI diagnosis.

Main Methods:

  • Systematic review of empirical studies on subjective cognitive complaints in Parkinson's disease.
  • Analysis of operationalization methods, data sources, and reported associations with cognitive impairment.
  • Evaluation of consistency and standardization in subjective cognitive complaint assessment.

Main Results:

  • A wide variety of measures are employed to assess subjective cognitive complaints in PD.
  • Significant inconsistency exists across studies regarding the methods, sources, quantity, and types of subjective cognitive complaints.
  • The association between subjective cognitive complaints and objective cognitive impairment varies across studies.

Conclusions:

  • The current lack of standardized measurement for subjective cognitive complaints poses a challenge for consistent PD-MCI diagnosis.
  • Methodological consensus is urgently needed for the reliable assessment of subjective cognitive complaints in Parkinson's disease.
  • Standardized measurement will improve diagnostic accuracy and research consistency in PD-MCI.
Keywords:
Parkinson's diseasemild cognitive impairmentsubjective cognitive complaints

More Related Videos

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Related Concept Videos

Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...