First Report on Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Isolates in Children Admitted to

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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

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Son Nguyen Thai1, Huong Vu Thi Thu2, Lien Vu Thi Kim2

  • 1Vietnam Military Medical University, Hanoi 151000, Vietnam.

Journal of Microbiology and Biotechnology
|August 23, 2019
PubMed

Insights

Multidrug-resistant methicillin-resistant Staphylococcus aureus (MRSA) is a significant threat in Vietnamese pediatric hospitals. Higher rates of resistance were observed in the north, with specific genetic types linked to distinct antibiotic resistance profiles.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a global healthcare concern due to its multidrug resistance (MDR).
  • Pediatric populations are particularly vulnerable to severe infections caused by resistant pathogens.

Purpose of the Study:

  • To investigate the prevalence and molecular characteristics of MDR-MRSA in children across two major Vietnamese tertiary care pediatric hospitals.
  • To compare antibiotic resistance patterns and genetic profiles between northern and southern Vietnam.

Main Methods:

  • Collected 168 MRSA strains for antibiotic susceptibility testing using minimum inhibitory concentration.
  • Conducted molecular characterization including antibiotic-resistant gene detection, pulsed-field gel electrophoresis, staphylococcal cassette chromosome mec (SCCmec) typing, and multilocus sequence typing.

Main Results:

  • The overall MDR rate was 51.8%, with significantly higher rates in the northern hospital (73%) compared to the southern hospital (39%).
  • Predominant MDR-MRSA resistance patterns included combinations of ciprofloxacin, erythromycin, gentamicin, and tetracyclines.
  • SCCmecII strains showed increased resistance to multiple antibiotics and harbored specific resistance genes; ST5-SCCmecII was dominant in the north, while SCCmecIVa predominated in the south.

Conclusions:

  • The study highlights significant MDR-MRSA prevalence in Vietnamese pediatric hospitals, raising public health concerns.
  • Distinct north-south differences in MRSA resistance and genetic structure suggest varied origins and antimicrobial usage patterns.
Keywords:
Methicillin-resistantStaphylococcus aureuschildrenmolecular patternmultidrug resistantvietnam

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