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Updated: Jan 20, 2026
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Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
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E-cigarettes compared with nicotine replacement therapy within the UK Stop Smoking Services: the TEC RCT
Peter Hajek1, Anna Phillips-Waller1, Dunja Przulj1
1Health and Lifestyle Research Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
Health Technology Assessment (Winchester, England)
|August 23, 2019
Summary
E-cigarettes were significantly more effective than nicotine replacement therapy (NRT) for smoking cessation in UK Stop Smoking Services. This study found e-cigarettes doubled quit rates and were more cost-effective, suggesting their wider adoption could improve success.
Area of Science:
- Public Health
- Clinical Trials
- Smoking Cessation
Background:
- UK Stop Smoking Services (SSSs) have hesitated to adopt e-cigarettes due to limited efficacy data compared to licensed smoking cessation aids.
- A significant number of UK smokers have used e-cigarettes to quit, highlighting a gap in current treatment options.
Purpose of the Study:
- To compare the effectiveness of refillable e-cigarettes versus nicotine replacement therapy (NRT) products.
- To evaluate these interventions when provided with weekly behavioral support through SSSs.
Main Methods:
- A randomized controlled trial involving 886 smokers seeking assistance to quit.
- Participants received either NRT or an e-cigarette starter pack, alongside standard weekly behavioral support.
- Outcomes were assessed at 52 weeks, with CO-validated sustained abstinence as the primary endpoint.
Main Results:
- The 1-year validated quit rate was significantly higher with e-cigarettes (18.0%) compared to NRT (9.9%).
- E-cigarette users reported better adherence, fewer urges to smoke, and more favorable product ratings.
- E-cigarette use was found to be more cost-effective for the NHS due to lower costs and higher quit rates.
Conclusions:
- E-cigarettes are a significantly more effective smoking cessation tool than NRT within a supported service context.
- Providing e-cigarette starter packs through SSSs has the potential to increase success rates and improve cost-effectiveness.
- Further research is needed to explore e-cigarette efficacy with varying levels of support.
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