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Updated: Jan 20, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Neoantigen quality, not quantity

Nicholas McGranahan1,2, Charles Swanton1,3

  • 1Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK. nicholas.mcgranahan.10@ucl.ac.uk charles.swanton@crick.ac.uk.

Science Translational Medicine
|August 23, 2019
PubMed

Insights

Targeting cancer neoantigens crucial for tumor survival may prevent treatment resistance. This strategy enhances the effectiveness of neoantigen therapies by focusing on essential cancer genes.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Genetics

Background:

  • Neoantigens are key targets for cancer immunotherapy.
  • Therapeutic resistance remains a significant challenge in cancer treatment.
  • Identifying neoantigens in essential cancer genes is a novel approach.

Purpose of the Study:

  • To investigate the impact of targeting essential neoantigens on therapeutic resistance.
  • To evaluate the potential of prioritizing neoantigens in cancer cell survival genes.

Main Methods:

  • Computational analysis of cancer genomes and transcriptomes.
  • Prioritization of neoantigens based on their origin from essential genes.
  • In silico modeling of neoantigen therapy response.

Main Results:

  • Neoantigens derived from genes critical for cancer cell survival were identified.
  • Prioritizing these essential neoantigens showed a theoretical reduction in resistance pathways.

Conclusions:

  • Targeting essential neoantigens may be a viable strategy to overcome resistance in cancer therapy.
  • This approach could improve the durability of response to neoantigen-based treatments.

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