Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Base Quantities and Derived Quantities01:14

Base Quantities and Derived Quantities

25.8K
In any system of units, the units for some physical quantities must be specified through a measurement process. These measurements are the base quantities of the system, and their units are the base units of the system. The algebraic combinations of the base values can then be used to express all other physical quantities. Each of these physical quantities is then referred to as a derived quantity, with each unit being referred to as a derived unit.
The International Organization for...
25.8K
Estimation of the Physical Quantities01:05

Estimation of the Physical Quantities

7.3K
On many occasions, physicists, other scientists, and engineers need to make estimates of a particular quantity. These are sometimes referred to as guesstimates, order-of-magnitude approximations, back-of-the-envelope calculations, or Fermi calculations. The physicist Enrico Fermi was famous for his ability to estimate various kinds of data with surprising precision. Estimating does not mean guessing a number or a formula at random. Instead, estimation means using prior experience and sound...
7.3K
Relating Angular And Linear Quantities - I01:09

Relating Angular And Linear Quantities - I

8.1K
If the rotational definitions are compared with the definitions of linear kinematic variables from motion along a straight line and motion in two and three dimensions, we can observe a mapping of the linear variables to the rotational ones.
When comparing the linear and rotational variables individually, the linear variable of position has physical units of meters, whereas the angular position variable has dimensionless units of radians, as it is the ratio of two lengths. The linear velocity...
8.1K
Relating Angular And Linear Quantities - II01:05

Relating Angular And Linear Quantities - II

6.4K
In the case of circular motion, the linear tangential speed of a particle at a radius from the axis of rotation is related to the angular velocity by the relation:
6.4K
Quality of Water01:19

Quality of Water

506
In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
506
Quality Control01:05

Quality Control

1.2K
Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunotherapy drug target identification using machine learning and patient-derived tumour explant validation.

Nature machine intelligence·2026
Same author

Evolutionary characterization of lung cancer metastasis.

Nature·2026
Same author

A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection, Prevention, and Interception.

Cancer discovery·2026
Same author

Molecular cancer prevention: Intercepting disease.

Molecular oncology·2026
Same author

Thymic health consequences in adults.

Nature·2026
Same author

Thymic health and immunotherapy outcomes in patients with cancer.

Nature·2026
Same journal

CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.

Science translational medicine·2026
Same journal

Bioresponsive microneedle stent provides anastomosis and postoperative adjuvant therapy in preclinical resectable intestinal diseases.

Science translational medicine·2026
Same journal

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026
Same journal

KSHV-infected endothelial cells expand and up-regulate angiogenic pathways and CXCR4 in patient-derived Kaposi sarcoma models.

Science translational medicine·2026
Same journal

Hypoxia-driven T cell-macrophage-stromal cross-talk sustains fibrosis in preclinical models of cutaneous chronic graft-versus-host disease.

Science translational medicine·2026
Same journal

Neurotensin receptor 2 agonism attenuates adverse cardiac remodeling in preclinical models.

Science translational medicine·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.2K

Neoantigen quality, not quantity.

Nicholas McGranahan1,2, Charles Swanton1,3

  • 1Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK. nicholas.mcgranahan.10@ucl.ac.uk charles.swanton@crick.ac.uk.

Science Translational Medicine
|August 23, 2019
PubMed
Summary
This summary is machine-generated.

Targeting cancer neoantigens crucial for tumor survival may prevent treatment resistance. This strategy enhances the effectiveness of neoantigen therapies by focusing on essential cancer genes.

More Related Videos

Preparation of High-Quality Fermented Fish Product
05:17

Preparation of High-Quality Fermented Fish Product

Published on: August 23, 2019

11.0K
Isolation of Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High Throughput Microplate Respiratory Measurements
10:12

Isolation of Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High Throughput Microplate Respiratory Measurements

Published on: November 13, 2015

13.3K

Related Experiment Videos

Last Updated: Jan 20, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.2K
Preparation of High-Quality Fermented Fish Product
05:17

Preparation of High-Quality Fermented Fish Product

Published on: August 23, 2019

11.0K
Isolation of Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High Throughput Microplate Respiratory Measurements
10:12

Isolation of Mitochondria from Minimal Quantities of Mouse Skeletal Muscle for High Throughput Microplate Respiratory Measurements

Published on: November 13, 2015

13.3K

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Genetics

Background:

  • Neoantigens are key targets for cancer immunotherapy.
  • Therapeutic resistance remains a significant challenge in cancer treatment.
  • Identifying neoantigens in essential cancer genes is a novel approach.

Purpose of the Study:

  • To investigate the impact of targeting essential neoantigens on therapeutic resistance.
  • To evaluate the potential of prioritizing neoantigens in cancer cell survival genes.

Main Methods:

  • Computational analysis of cancer genomes and transcriptomes.
  • Prioritization of neoantigens based on their origin from essential genes.
  • In silico modeling of neoantigen therapy response.

Main Results:

  • Neoantigens derived from genes critical for cancer cell survival were identified.
  • Prioritizing these essential neoantigens showed a theoretical reduction in resistance pathways.

Conclusions:

  • Targeting essential neoantigens may be a viable strategy to overcome resistance in cancer therapy.
  • This approach could improve the durability of response to neoantigen-based treatments.