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Marshall J Colville1, Sangwoo Park2, Warren R Zipfel2,3,4

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A new, affordable instrument control platform synchronizes microscopy components for precise azimuthal scanning. This open-source system minimizes image artifacts in advanced techniques like scanning angle interference microscopy (SAIM).

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Area of Science:

  • Microscopy
  • Optical Physics
  • Instrumentation

Background:

  • Azimuthal beam scanning addresses uneven excitation fields in total internal reflection fluorescence (TIRF) microscopy.
  • Scanning angle interference microscopy (SAIM) requires precise laser beam control, posing technical challenges for custom microscope construction.
  • Accurate synchronization is crucial for high-quality data and minimizing sample damage in SAIM.

Purpose of the Study:

  • To develop an affordable, programmable, and versatile instrument control platform for advanced microscopy.
  • To address the technical challenges of precision control in azimuthal scanning for SAIM.
  • To improve data quality and reduce sample damage in advanced microscopy techniques.

Main Methods:

  • Developed an instrument control platform inspired by open-source systems like Arduino.
  • Integrated precision analog circuitry and optimized firmware for microscopy applications.
  • Incorporated waveform generation, multiplexed analog outputs, and hardware triggers into a central hub.

Main Results:

  • The platform enables fast circle-scanning acquisitions, including azimuthal scanning SAIM and multiangle TIRF.
  • Low communication latency reduces image intensity and reconstruction artifacts caused by synchronization errors.
  • The system offers an affordable and user-friendly solution for advanced microscopy control.

Conclusions:

  • The developed platform provides a versatile solution for azimuthal scanning in SAIM and multiangle TIRF.
  • Open-source hardware and software facilitate community development and collaboration.
  • This approach enhances data quality and minimizes artifacts in advanced microscopy by improving synchronization.