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R(-)-baclofen: focal epilepsy after intracortical administration in the rat
C M Van Rijn1, M J Van Berlo, M G Feenstra
1Institute of Neurology, University of Nijmegen, The Netherlands.
Epilepsy Research
|November 1, 1987
Abstract:
R(-)- or S(+)-baclofen were injected into lamina IV-V of the sensorimotor cortex of the rat. Clinical observation and ECoG registration revealed that partial epilepsy with focal motor symptoms developed following injection of R(-)-baclofen, with an ED50 of 0.25 nmoles, a mean latency of 17 min independent of the dose, and a duration of more than 5 h at a dose of 5 nmoles. S(+)-Baclofen was ineffective at doses of up to 5 nmoles (2 x ED100 (-)-baclofen), indicating a stereoselective action of the (-)-isomer.