Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biochemical markers of aging.

E R Stadtman1

  • 1Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892.

Experimental Gerontology
|January 1, 1988
PubMed
Summary

Metabolic deficiencies, particularly changes in enzyme activity and coenzyme ratios, may serve as biochemical markers for aging. Monitoring these metabolic shifts can help identify age-related physiological changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pro-oxidant activity of Cu,Zn-superoxide dismutase.

Age·2013
Same author

Storage of dried fruit; influence of moisture and sulfur dioxide on deterioration of apricots.

Industrial and engineering chemistry·2010
Same author

Sixty years of research: from soil science and the browning of dried apricots to the biochemistry of metabolism.

Cellular and molecular life sciences : CMLS·2004
Same author

Ageing and exposure to oxidative stress in vivo differentially affect cellular levels of PrP in mouse cerebral microvessels and brain parenchyma.

Neuropathology and applied neurobiology·2004
Same author

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins.

Amino acids·2003
Same author

Recent advances in the analysis of oxidized proteins.

Amino acids·2003

Area of Science:

  • Biochemistry
  • Gerontology
  • Metabolic Regulation

Background:

  • Aging is characterized by numerous physiological and physical changes.
  • These changes may stem from altered enzyme regulation and activity in central metabolic pathways.

Purpose of the Study:

  • To identify potential metabolic deficiencies as biochemical markers of aging.
  • To explore age-related alterations in specific enzyme systems and metabolic ratios.

Main Methods:

  • Investigating age-related changes in allosteric enzymes, futile substrate cycling enzymes, and coenzyme-dependent enzymes.
  • Examining enzymes regulated by phosphorylation/dephosphorylation and G-protein-dependent systems.
  • Monitoring coenzyme substrate pairs, energy charge ratios, and second messenger concentrations.

Main Results:

  • Alterations in enzyme activity and regulation are proposed as key indicators of aging.
  • Specific enzyme classes and metabolic ratios (e.g., NAD+/NADH, energy charge) may serve as reliable aging markers.
  • Accumulation of altered enzyme forms due to imbalanced modification and degradation is linked to aging.

Conclusions:

  • Metabolic deficiencies and shifts in enzyme function are potential biochemical markers for aging.
  • Monitoring key metabolic parameters can provide insights into the aging process.
  • Understanding these mechanisms is crucial for addressing age-related metabolic decline.

Related Experiment Videos