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Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair
Kevin Schilling1,2, Mirna El Khatib3, Shane Plunkett3
1Department of Biomedical Engineering , University of Rochester , Rochester , New York 14620 , United States.
ACS Applied Materials & Interfaces
|August 23, 2019
Summary
Researchers developed oxygen-reporting fibers for real-time monitoring of tissue oxygenation during bone healing. This innovation aids in understanding bone repair and advancing tissue engineering for better bone regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Biomedical Imaging
Background:
- Tissue oxygenation is critical for bone repair and regeneration.
- Current methods struggle to deliver oxygen probes to avascular healing sites.
- Two-photon phosphorescence lifetime microscopy (2PLM) offers high-resolution oxygen imaging.
Purpose of the Study:
- To create a novel oxygen-reporting fibrous matrix for bone tissue engineering.
- To enable minimally invasive, real-time 3D mapping of oxygen in healing bone defects.
- To support cell growth and differentiation while monitoring oxygen levels.
Main Methods:
- Coaxial electrospinning to encapsulate a hydrophilic oxygen-sensitive probe (PtP-C343) within fibers.
- Utilizing the fibers as a delivery vehicle for the probe into the microenvironment.
- Employing 2PLM and a cranial defect window chamber model for in vivo imaging.
Main Results:
- Fabricated multifunctional oxygen-reporting fibrous matrix.
- Demonstrated support for bone marrow stromal cell growth and differentiation.
- Enabled real-time, high-resolution 3D oxygen mapping in vivo during bone healing.
Conclusions:
- The oxygen-reporting fibers serve as an effective tool for minimally invasive oxygen monitoring in bone healing.
- This technology facilitates research into bone regeneration processes.
- It aids in the design of advanced tissue-engineered constructs for enhanced bone repair.
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