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Prevalence of MET exon 14 skipping mutation in pulmonary sarcomatoid carcinoma patients without common targetable

Yongfeng Yu1, Qing Zhang2, Jie Zhang2

  • 1Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Journal of Cancer Research and Therapeutics
|August 23, 2019
PubMed
Abstract

Insights

MET ex14 skipping mutation occurs in 9% of pulmonary sarcomatoid carcinoma patients lacking common mutations. This finding aids genetic counseling and treatment for this rare lung cancer subtype.

Area of Science:

  • Oncology
  • Genetics
  • Pulmonology

Background:

  • Pulmonary sarcomatoid carcinoma (PSC) is a rare non-small cell lung cancer subtype.
  • Limited targeted treatment options exist for PSC.
  • Investigating novel mutations is crucial for advancing PSC treatment.

Purpose of the Study:

  • To determine the prevalence of MET ex14 skipping mutations in PSC patients.
  • To identify PSC patients with specific genetic alterations for targeted therapies.
  • To assess the potential of MET ex14 skipping as a therapeutic target in PSC.

Main Methods:

  • Next-generation sequencing (NGS) was used to analyze 46 PSC specimens.
  • The Oncomine Focus Assay was employed for mutation detection.
  • Patients with common mutations (EGFR, KRAS, ALK, ROS1, RET) were excluded.

Main Results:

  • MET ex14 skipping mutation was identified in 9% (4/46) of PSC patients.
  • This was the sole mutation detected within the analyzed gene panel.
  • No significant differences in overall survival or disease-free survival were observed between mutation-positive and negative groups.

Conclusions:

  • MET ex14 skipping mutation prevalence is approximately 9% in Chinese PSC patients lacking other common targetable mutations.
  • Findings support genetic counseling and targeted treatment strategies for these patients.
  • Further large-scale studies are needed to clarify the prognostic and clinical significance of MET ex14 skipping in PSC.
Keywords:
METex14 skippingnext-generation sequencingpulmonary sarcomatoid carcinoma

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