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Updated: Jan 20, 2026

Electroeluting DNA Fragments
Published on: September 5, 2010
Synthesis of the GHIJKL Fragment of Gymnocin-B
Takeo Sakai1, Hideaki Sakakibara1, Yumi Omoto1
1Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
Abstract:
The GHIJKL fragment of gymnocin-B was synthesized using the oxiranyl anion strategy. The first highlight of the synthesis is the bromoketone cyclization reaction on the oxepane ring to construct the fused bisoxepane GH ring. The second key step is the introduction of the trans-4-hydroxy-3-methyloxepane J ring via addition of trimethylaluminum to a conjugated oxonium moiety, followed by diastereoselective epoxidation and regioselective reduction.
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