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Related Experiment Video

Updated: Jan 20, 2026

Author Spotlight: Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies
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Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization.

Yun-Fan Zhou1,2, Lian-Jun Shi1,2, Jin Yao1,2

  • 1The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China.

Cornea
|August 23, 2019
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are involved in corneal neovascularization. Specific circRNAs, cZFP609 and cKifap3, show dysregulation and may be therapeutic targets for treating this condition.

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Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Corneal neovascularization (CNV) is a major cause of vision loss.
  • The role of circular RNAs (circRNAs) in CNV pathogenesis is not well understood.

Purpose of the Study:

  • To identify differentially expressed circRNAs in corneal neovascularization.
  • To investigate the functional roles of these circRNAs in angiogenesis.

Main Methods:

  • An alkali burn-induced CNV mouse model was used for circRNA expression profiling.
  • Bioinformatic analyses (GO, KEGG) identified host genes and pathways.
  • Real-time PCR and in vitro assays validated circRNA expression and function.

Main Results:

  • 229 circRNAs were differentially expressed in CNV corneas.
  • Host genes were enriched in cell cycle, cytoplasm, and protein binding.
  • Rap1 signaling pathway was significantly enriched.
  • cZFP609 and cKifap3 were dysregulated in human CNV corneas.
  • cKifap3 silencing promoted endothelial cell proliferation, migration, and tube formation.

Conclusions:

  • circRNAs play a significant role in the pathogenesis of corneal neovascularization.
  • cZFP609 and cKifap3 are potential therapeutic targets for CNV treatment.