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Related Experiment Video

Updated: Jan 20, 2026

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

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Cardiac mucormycosis: a case report.

Darshan Krishnappa^1,2, Sanjeev Naganur¹, Dinesh Palanisamy³

¹Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

European Heart Journal. Case Reports

|August 23, 2019

Summary

Mediastinal mucormycosis, a rare fungal infection, can rapidly progress and be fatal, even in immunocompetent individuals. Early diagnosis and treatment are crucial for this invasive fungal infection.

Keywords:

Immunocompromise Cardiac mucormycosis Case report Immunocompetent Invasive fungal infection Mediastinal mucormycosis

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Area of Science:

Mycology
Infectious Diseases
Cardiology

Background:

Mucormycosis is an invasive fungal infection (IFI) primarily affecting immunocompromised individuals.
Classical risk factors include diabetic ketoacidosis, transplantation, iron overload, and deferoxamine therapy.
While cutaneous and rhino-sinusoidal forms occur in immunocompetent (IC) individuals, cardiac and mediastinal involvement is rare.

Purpose of the Study:

To report a rare case of mediastinal mucormycosis with extensive cardiac involvement in a young patient without predisposing factors.
To highlight the rapid progression and high fatality associated with this condition in immunocompetent individuals.

Main Methods:

A 19-year-old male presented with cough and dyspnea.
Echocardiography and CT chest revealed diffuse mediastinal and cardiac infiltration.
Fine needle aspiration cytology confirmed Mucor species.

Main Results:

The patient presented with mediastinal mucormycosis and extensive cardiac involvement, including bilateral atria, interatrial septum, pulmonary veins, and superior vena cava.
No predisposing factors for invasive fungal infection were identified.
Despite Amphotericin B treatment, surgical debridement was not feasible due to diffuse infiltration, and the patient succumbed to the illness.

Conclusions:

Mediastinal mucormycosis is a rare but rapidly progressive and often fatal condition, even in immunocompetent patients.
A high index of suspicion is necessary for early diagnosis of infiltrative mediastinal disorders.
Prompt diagnosis and treatment are critical for improving outcomes in invasive fungal infections like mucormycosis.