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Acupuncture for chronic hepatitis B.

De Zhao Kong1, Ning Liang, Guan Lin Yang

  • 1Liaoning University of Traditional Chinese Medicine, Chong Shan East Road 79, Shenyang, Liaoning Province, China, 110032.

The Cochrane Database of Systematic Reviews
|August 23, 2019
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Summary
This summary is machine-generated.

The clinical effectiveness of acupuncture for chronic hepatitis B is uncertain due to limited, low-quality evidence. More rigorous research is needed to determine its benefits and harms in managing this liver disease.

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Area of Science:

  • Hepatology
  • Complementary and Alternative Medicine
  • Clinical Research Methodology

Background:

  • Chronic hepatitis B (CHB) is a significant cause of liver disease morbidity and mortality.
  • Long-term management of CHB aims to prevent severe complications like liver cirrhosis and cancer.
  • Acupuncture is explored for symptom management and immune function improvement in CHB patients, but its efficacy and safety require rigorous evaluation.

Purpose of the Study:

  • To systematically assess the benefits and harms of acupuncture compared to no intervention or sham acupuncture in individuals with chronic hepatitis B.

Main Methods:

  • Conducted comprehensive electronic searches across multiple databases and clinical trial registries up to March 2019.
  • Included randomized clinical trials (RCTs) regardless of publication status, language, or blinding.
  • Extracted data on primary outcomes (mortality, serious adverse events, quality of life) and secondary outcomes (hepatitis B-related events, non-serious adverse events).

Main Results:

  • Included eight RCTs with 555 participants, all comparing acupuncture to no intervention; interventions and co-interventions were heterogeneous.
  • All trials exhibited a high risk of bias, leading to very low certainty of evidence for all outcomes.
  • Uncertainty exists regarding acupuncture's effect on non-serious adverse events, hepatitis B e-antigen (HBeAg) status, and hepatitis B virus (HBV) DNA levels.

Conclusions:

  • The clinical effects of acupuncture for chronic hepatitis B remain largely unknown due to insufficient high-quality evidence.
  • Existing trials lack data on crucial patient-relevant outcomes such as mortality and quality of life.
  • Future research should focus on large, high-quality, sham-controlled RCTs with transparent funding to establish acupuncture's true impact on CHB.