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Re-elevation of serum amlodipine level after lipid emulsion therapy in an overdose case
Motozumi Ando1, Shinji Nakasako2, Koichi Ariyoshi3
1Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan.
What Is Known And Objective:
Amlodipine overdose is common; however, the dose and timing of intravenous lipid emulsion (ILE) therapy as a management strategy remain debatable.
Case Description:
A 73-year-old man received a single bolus (1.5 mL/kg) of ILE therapy following massive ingestion of multiple drugs, including amlodipine. After approximately 20 hours of ILE therapy, the serum amlodipine level that had decreased from 90.2 to 49.9 ng/mL increased to 70.8 ng/mL.
What Is New And Conclusion:
A single bolus (1.5 mL/kg) of ILE therapy is probably insufficient to completely capture and partition serum amlodipine following amlodipine overdose.
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