Pyrimidine Nucleosides from Streptomyces sp. SSA28
Cheng-Dong Xu1, Hao-Jian Zhang1, Zhong-Jun Ma1
1Institute of Marine Biology and Pharmacology, Ocean College , Zhejiang University , Zhoushan 316021 , People's Republic of China.
Abstract:
Eleven new pyrimidine nucleosides (1-11) and 12 known analogues (12-23) were isolated from the marine-derived Streptomyces sp. SSA28. All of the new structures were elucidated by extensive NMR spectroscopic analysis and HRESIMS data. The absolute configurations of compound 1 were determined by X-ray diffraction. The configurations of 2-16 were investigated by ECD calculations. Compounds 11-16 showed cytotoxicity against HCT-116 human colon cancer cell lines with IC50 values from 0.39 ± 0.03 to 6.63 ± 0.47 μM.
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