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Effectiveness of non-pharmacological interventions for insomnia in children with Autism Spectrum Disorder: A
Sophie Keogh1, Christopher Bridle2, Niroshan A Siriwardena2
1Lincolnshire Partnership Foundation Trust, Lincoln, United Kingdom.
Insights
Behavioral interventions significantly improve sleep in children with autism spectrum disorder (ASD), increasing total sleep time and efficiency. These findings offer hope for better sleep quality in this population.
Area of Science:
- Neurodevelopmental Disorders
- Pediatric Sleep Medicine
Background:
- Autism spectrum disorders (ASD) are neurodevelopmental conditions marked by social, communication, and behavioral challenges.
- Sleep disturbances affect 40-80% of children with ASD, impacting their quality of life and that of their caregivers.
Purpose of the Study:
- To systematically review and synthesize evidence on the effectiveness of behavioral interventions for improving sleep in children with ASD.
Main Methods:
- A comprehensive search of multiple databases (MEDLINE, PsycINFO, CINAHL, etc.) was conducted for randomized controlled trials.
- Included studies evaluated non-pharmacological interventions for insomnia in children diagnosed with ASD.
Main Results:
- Meta-analyses of three studies showed significant improvements in total sleep time (24.41 min), reduced sleep latency (-18.31 min), and increased sleep efficiency (5.59%) based on actigraphy data.
- Subjective data from the Children's Sleep Habits Questionnaire (CSHQ) also indicated a favorable intervention effect (-4.71).
- The overall risk of bias in the included studies was low, though some reporting was unclear.
Conclusions:
- This systematic review provides initial quantitative evidence supporting the effectiveness of behavioral interventions for sleep problems in children with ASD.
- Despite a limited number of high-quality randomized controlled trials, the findings suggest that behavioral approaches are beneficial.
Background:
Autism spectrum disorders (ASD) are a set of neurodevelopmental disorders characterised by behavioural, communication and social impairments. The prevalence of sleep disturbances in children with ASD is 40-80%, with significant effects on quality of life for the children and carers. This systematic review aimed to synthesise evidence of the effects of behavioural interventions to improve sleep among children with ASD.
Methods:
Databases (MEDLINE, PsycINFO, CINAHL, ScienceDirect, Autism Data, CENTRAL, ClinicalTrials.gov and Current Controlled Trials) were searched for published, unpublished and ongoing randomised controlled trials evaluating the effect of non-pharmacological interventions for insomnia in children with autism spectrum conditions.
Results:
Three studies met the inclusion criteria, one provided actigraphy data, one Children's Sleep Habits Questionnaire (CSHQ) data, and one both actigraphy and CSHQ data for use in meta-analyses. There were significant differences between the behavioural intervention and comparison groups (actigraphy data) for total sleep time (24.41 minutes, 95% CI 5.71, 43.11, P = 0.01), sleep latency (-18.31 minutes, 95% CI -30.84, -5.77, P = 0.004) and sleep efficiency (5.59%, 95% CI 0.87, 10.31, P = 0.02). There was also a favourable intervention effect evident for the subjective CSHQ data (-4.71, 95% CI -6.70, -2.73, P<0.00001). Risk of bias was low across several key domains (randomisation, allocation concealment and reporting), with some studies being unclear due to poor reporting.
Conclusions:
There are very few high quality randomised controlled trials in this area. Here we provide initial synthesised quantitative evidence of the effectiveness of behavioural interventions for treating sleep problems in children with ASD.
Trial Registration:
Protocol was registered (CRD42017081784) on the International Prospective Register of Systematic Reviews (http://www.crd.york.ac.uk/PROSPERO).
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