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Updated: Jan 20, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles
Olena Savych1,2, Yuliya O Kuchkovska1,3, Andrey V Bogolyubsky1
1Enamine, Ltd. , Chervonotkatska Street 78 , Kyiv 02094 , Ukraine , www.enamine.net.
Abstract:
Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsymmetrical thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chemical space covered by the method exceeded 7 million feasible compounds.
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